On June 22, the kick-off meeting for the "Research on the Mechanism of Enzyme-Catalyzed In Situ Dynamic Molecular Transformation Based on Ultra-Polarized NMR," a B-type pilot special project of the Chinese Academy of Sciences (CAS) led by APM, was held in Wuhan. More than 60 people attended the meeting, including experts from the project's scientific advisory and guidance team such as YE Chaohui, ZHANG Yukui, and LIU Maili, all academicians of the CAS; HE Peng, project manager of the Physics and Chemistry Division of the Bureau of Frontier Sciences and Education of the CAS; NI Sidao, academician of the CAS and deputy director of APM; LI Conggang, the principal investigator of APM; project leaders and key research members; and heads of relevant management departments.

Representing the host institution of the special project, Academician NI Sidao expressed gratitude to all experts for their strong support and assistance. He indicated that APM would deeply understand the significant strategic importance of seizing the commanding heights of science and technology, earnestly listen to the opinions and suggestions of all experts, make every effort to provide support and guarantee, and ensure the high-quality progress of the special project's organization and implementation.

LI Conggang presented an overall implementation plan report, systematically introducing the positioning, research plan and technical route, research objectives and evaluation indicators, research team, organization and management, and other aspects of the special project. Four project leaders, namely Researchers XU Jun, LI Conggang, ZHANG Xu, and GUO Qianni, respectively reported on the specific implementation of each project.

This special project focuses on the important scientific frontier of the dynamic transformation mechanism of enzyme-catalyzed molecules and conducts innovative interdisciplinary research on the “mechanism of in-situ molecular transformation based on ultra-sensitive nuclear spin” at the levels of isolated systems, cells, and living organisms, centering on energy-related enzyme mimics and important biological enzyme catalytic systems. After carefully listening to the reports, the expert group unanimously agreed that the research objectives were clear, the research content was specific, and the overall design route was clear, with smooth progress so far. In addition, the experts also provided targeted opinions and suggestions for the follow-up work of the special project, hoping for good overall coordination, collaborative efforts, and striving to achieve breakthrough research results.

the meeting scene